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Protein interactions play important role in biological field and hence their characterization to reveal their structure and functionhas become important.In absence of experimentally determined structures, proteins can be modeled using computational methods. There is an increase in number of known protein sequences since the computational tools for modelling have been built. Modeller is one of […]

The last century has been encompassed with the development of numerous experimental methods that help us understand the human body better. Proteins are one of the key functional units in our bodies that make us who we are and allow us to perform the functions we can. the indispensable role of proteins can be actively […]

Phylogenetics has deemed to be a very vital method to identify relationships between microorganisms and has now entered into solving criminal investigations. Phylogenetics can be defined as the study of the evolutionary relationships between species, individuals or even the genes. Phylogenetics now has found its way as a vital technique in forensics identifying the path [...]

One of the best outcomes of computational integration with biology is molecular docking. Molecular docking is a method that is used to determine the interaction between two molecules (protein-protein/ protein-ligand etc..).Molecular docking uses an algorithm which incorporates various other algorithms like search algorithm, which on the basis of small size and the moiety that fits [...]

Pharmacophore is the essential to understand the interaction between the receptor and ligand. It is important feature to design new drug for treatment of the intended disease. Pharmacophore defined as the essential geometric arrangement of atoms or functional groups necessary to produce a given biological response. The strict IUPAC definition of a pharmacophore is: A […]

With the recent advancement in DNA sequencing technologies, researches have been fortified to high-throughput, cost-efficient sequencing of many more genomes that was ever previously possible. The most prominent area of genomic sequencing and assembly, known as de-novo genome assembly, now-a-days makes it even possible for researchers to individually sequence the genome of their choosing organisms. […]

The human genome project showed that important genetic variations exist between individuals. The 1000 genomes project measures those genetic variations between individuals which help medical researchers to find disease causing gene. All the different genes found in the cells of human being are the human genome and it is the key to what makes us […]

Precise and efficient genome editing has triggered a revolution in making genetic manipulations possible essentially in all types of cells and organisms. There are many approaches like ZFNs and TALENs have been developed for genome editing. Among which, the most recent and broadly applicable one is CRISPR-Cas9 which is short for Clustered Regularly Interspaced Short […]

Protein-Protein docking is a kind of bioinformatics tool for studying protein-protein interaction. Protein-protein interaction plays important role in biological processes like signal transduction, cellular motion, gene regulation and transport, it is the way to find target for drug discovery. Generally, the protein structures which had high resolution and were determined by X-ray crystallography was considered […]

To understand the mechanism behind the function of a protein, its three-dimensional structure plays a central role. Various experimental methods to determine protein three-dimensional structure like X-ray crystallography, NMR, electron microscopy, etc. provide more authentic structures than the theoretical models but they are very time consuming and have their limits, as in case of membrane […]