Computer Aided Drug Discovery

Primer Designing By Primer Blast Primers serve a crucial function in identifying the target area of the complex genome [1]. Primers or oligonucleotides are short sequences of DNA or RNA that are complementary to a particular DNA sequence, allowing replication to occur during a PCR cycle. Primers may also be used in various techniques, including […]

DeepMind’s artificial intelligence system AlphaFold2, predicts the 3D structure of a protein based on its amino acid sequence. It looks to be a 50-year-old answer to the problem of protein folding. DeepMind’s AlphaFold1 was the first in the series, and it scored high in the 13th Critical Assessment of Protein Structure Prediction (Deepmind’s first effort […]

The production of large amount of compounds is the characterization of modern drug discovery. This huge libraries of compounds need to be examine in short periods of time. So, Computer aided drug design has came out as a method for developing candidate drug for treatment of many disease types. The discovery of drug and developing […]

Computer aided drug designing aims for medical chemistry that designs methods in modern medicinal chemistry such that its’ cost with respect to depletes and it uses one fastest growing approach of pharmacophore modeling. Pharmacophore modeling is a technique where a large number of molecules can be filtered and segregate molecules on few or more identical […]

Pharmacophore is the essential to understand the interaction between the receptor and ligand. It is important feature to design new drug for treatment of the intended disease. Pharmacophore defined as the essential geometric arrangement of atoms or functional groups necessary to produce a given biological response. The strict IUPAC definition of a pharmacophore is: A […]